Journal article
The molecular epidemiology of the highly virulent st93 australian community staphylococcus aureus strain
GW Coombs, RV Goering, KYL Chua, S Monecke, BP Howden, TP Stinear, R Ehricht, FG O'Brien, KJ Christiansen
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
In Australia the PVL - positive ST93-IV [2B], colloquially known as "Queensland CA-MRSA" has become the dominant CA-MRSA clone. First described in the early 2000s, ST93-IV [2B] is associated with skin and severe invasive infections including necrotizing pneumonia. A singleton by multilocus sequence typing (MLST) eBURST analysis ST93 is distinct from other S aureus clones. To determine if the increased prevalence of ST93-IV [2B] is due to the widespread transmission of a single strain of ST93-IV [2B] the genetic relatedness of 58 S. aureus ST93 isolated throughout Australia over an extended period were studied in detail using a variety of molecular methods including pulsed-field gel electroph..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was supported by PathWest Laboratory Medicine - WA, Curtin University, the Western Australian Department of Health and the National Health and Medical Research Council of Australia Project Grant 1008656. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.